This clinical trial investigated Jin’s three-needling (J3N) acupuncture therapy for GAD by comparing it with standard pharmacologic treatment and a combined approach. Acupuncture produced similar overall clinical outcomes to medication but demonstrated a higher efficacy index and significantly reduced biomarkers associated with anxiety, including ACTH and platelet serotonin, suggesting it may be an effective alternative or adjunct therapy.

This RCT evaluated art therapy versus a waiting-list control in adult women with moderate to severe anxiety disorders. The intervention significantly reduced anxiety symptoms and improved quality of life and emotion regulation, with large effect sizes. Benefits were maintained at 3-month follow-up, and improvements in emotional acceptance and goal-directed behavior were associated with reductions in anxiety.

This RCT assigned 65 GAD patients to face-to-face EMDR, web-based EMDR, or a waiting-list control (10 sessions each). Both active treatment arms significantly reduced anxiety symptoms relative to the control condition, with comparable efficacy between formats, supporting web-based EMDR as a viable alternative to in-person therapy.

This large RCT (n=1,007) assigned patients with knee osteoarthritis to true acupuncture, sham acupuncture, or usual care over 8 weeks. True acupuncture produced significantly greater improvements in pain and function compared with both sham acupuncture and usual care, although sham acupuncture also outperformed usual care, suggesting both specific and nonspecific therapeutic effects.

This preclinical study used a rabbit model of osteoarthritis to evaluate the effects of Du-Huo-Ji-Sheng-Tang on cartilage degradation. Treatment significantly reduced cartilage degeneration, downregulated catabolic and inflammatory markers, and preserved joint structure compared to untreated controls, suggesting a protective effect against OA progression.

This RCT (n=60) evaluated art therapy (marbling art with ney music, five sessions over 10 weeks) in postoperative breast cancer patients during chemotherapy. Results showed statistically significant reductions in pain, nausea/vomiting, and anxiety, along with improved quality of life, with greater improvements observed as sessions accumulated.

In this RCT (n=190), women with breast cancer experiencing hot flashes were assigned to acupuncture plus self-care or self-care alone (10 sessions over 12 weeks). The acupuncture group had a significantly lower hot flash score at 12 weeks, and the reduction was maintained at 3- and 6-month follow-up.

In this placebo-controlled trial (n=120), electroacupuncture produced the greatest and longest-lasting reduction in hot flash symptom severity, outperforming sham acupuncture, gabapentin, and placebo pills. The gabapentin group experienced the most side effects including dizziness and somnolence.

This review synthesized clinical trials evaluating yoga therapy as a supportive intervention during cancer treatment. Across 4–12 week interventions, evidence demonstrated consistent improvements in fatigue, sleep quality, psychological distress, and quality of life, with some variability in effect size due to heterogeneity in study design and intervention protocols.

This RCT (n=51) evaluated a structured 16-hour mandala art therapy program for mothers of children with special needs. Results demonstrated statistically significant improvements in both comfort and resilience scores compared to controls, indicating that mandala art therapy effectively enhanced psychological well-being in this population.

This RCT evaluated acupuncture in mild-to-moderate Carpal Tunnel Syndrome compared to standard therapy (wrist splinting and/or medication). After approximately 4 weeks of treatment, the acupuncture group demonstrated significantly greater improvements in symptom severity, functional status, and electrophysiological parameters, suggesting acupuncture as an effective adjunctive treatment.

This network meta-analysis compared multiple art therapy modalities (music therapy, reminiscence therapy, painting/drawing, and combined creative therapies) in patients with dementia. Music therapy and combined multimodal art therapies ranked highest for improving cognitive function and reducing behavioral and psychological symptoms, supporting art-based interventions as effective non-pharmacologic strategies for dementia care.

This systematic review and meta-analysis of 21 RCTs (n=1,943) found that acupuncture combined with conventional treatments was associated with statistically significant reductions in fasting blood glucose and HbA1c compared with sham acupuncture or conventional treatments alone. Participants also showed improvements in blood lipid levels, blood pressure control, and weight management.

This RCT (n=62) treated type II diabetes patients with confirmed neuropathy symptoms with 12 acupuncture sessions over 8 weeks combined with conventional care. The acupuncture group experienced statistically significant reductions in neuropathic symptoms, quality of life improvements on the DPNPI scale, and these improvements remained clinically meaningful for 4 weeks post-treatment.

In this animal-model study, diabetic rats administered Chinese herbal Yuquan pills showed a higher maximum plasma concentration and substantially increased elimination half-life of metformin compared to controls, signaling both potential to increase drug efficacy and a need for caution regarding herb-drug interactions between anti-diabetic herbs and medications.

This controlled clinical study evaluated the effects of acupuncture on obesity and associated fluid regulation. Results indicated significant reductions in body weight along with modulation of fluid balance, suggesting effects on sodium and water metabolism and supporting acupuncture as a potentially beneficial adjunct for obesity management.

This systematic review and meta-analysis of RCTs found that acupuncture significantly reduced pelvic pain and dysmenorrhea, improved quality of life, and in some cases lowered CA-125 levels and lesion size compared to controls, supporting acupuncture as an effective adjunctive therapy for endometriosis management.

This systematic review and meta-analysis of 17 RCTs (n=1,389) found that acupuncture combined with Western medicine showed significantly higher overall treatment effectiveness compared to Western medicine alone, including reduced seizure frequency, improved EEG outcomes, and improved self-reported quality of life.

This multicenter, three-arm RCT (n=150) compared body acupuncture, Sa-am acupuncture, and usual care alone for CFS/ICF. Both acupuncture groups received 10 sessions over 4 weeks and showed significantly greater reductions in fatigue severity compared to usual care alone, supporting acupuncture as an effective adjunctive treatment.

This systematic review and meta-analysis of 30 RCTs (n=3,503) demonstrated that acupuncture produced significantly greater improvements in pain (VAS), functional outcomes (JOA scores), and overall clinical effectiveness compared to NSAIDs, lumbar traction, and combination medical therapies, though study heterogeneity and risk of bias highlighted the need for higher-quality trials.

This meta-analysis of RCTs found that acupuncture significantly reduced both systolic and diastolic blood pressure—particularly when used adjunctively with antihypertensive drugs—while demonstrating a favorable safety profile, though heterogeneity and methodological limitations reduced overall evidence certainty.

This randomized, double-blind, placebo-controlled trial evaluated a Chinese herbal formula for masked hypertension over 8 weeks, assessed via 24-hour ambulatory blood pressure monitoring. The herbal formula significantly reduced both daytime and nighttime ambulatory blood pressure compared to placebo, indicating a beneficial effect on out-of-office blood pressure control.

This systematic review and meta-analysis of RCTs found that combined acupuncture and Chinese herbal medicine therapy significantly improved global IBS symptoms, reduced diarrhea frequency, and demonstrated higher overall response rates compared to Western medications, acupuncture alone, or herbal therapy alone.

This narrative review synthesized evidence on mechanisms by which acupuncture and moxibustion influence IBS symptoms, including modulation of gastrointestinal motility, visceral hypersensitivity, brain-gut axis signaling, inflammatory cytokines, and autonomic nervous system activity, supporting its role as a complementary therapy with multi-system regulatory effects.

This RCT demonstrated that acupuncture significantly improved sleep quality, sleep latency, and overall symptom scores (PSQI) compared to the control group, with minimal adverse effects, supporting acupuncture as a safe and effective treatment option for primary insomnia.

In this RCT (n=72), women receiving 3 acupuncture sessions around embryo transfer had significantly greater positive β-hCG rates (63.9%) compared to the control group (33.3%). Anxiety levels were also significantly reduced in the acupuncture group.

In this foundational RCT (n=160), clinical pregnancies were documented in 42.5% (34/80) of the acupuncture group versus 26.3% (21/80) in the control group following embryo transfer, establishing an early evidence base for acupuncture’s role in improving IVF outcomes.

This meta-analysis of 38 RCTs (n=5,991) found that acupuncture during controlled ovarian hyperstimulation significantly improved clinical pregnancy rates, and acupuncture before frozen embryo transfer markedly increased both clinical pregnancy rate and live birth rate. Live birth rate only improved with high-dosage protocols.

This systematic review of 25 trials (n=4,757) found that acupuncture participants had a significantly higher clinical pregnancy rate (43.6% vs. 33.2%) and live birth rate (38% vs. 28.7%) compared to controls. Acupuncture during ovarian hyperstimulation and embryo transfer phases yielded more favorable outcomes, and electrical acupuncture appeared more effective than manual acupuncture.

This RCT compared group art therapy (~8–10 weekly sessions) versus a control group in older adults living alone. Results showed statistically significant reductions in both loneliness and hopelessness scores in the intervention group, indicating that group art therapy can be an effective psychosocial intervention for improving emotional well-being in socially isolated older adults.

This RCT evaluated brief Somatic Experiencing (SE, ~6–10 sessions) for patients with chronic low back pain and comorbid PTSD symptoms. Results demonstrated significant reductions in PTSD symptom severity and modest improvements in pain-related outcomes in the SE group, suggesting SE may be a beneficial adjunctive therapy for individuals with overlapping chronic pain and trauma symptoms.

This pragmatic RCT assigned peri- and postmenopausal women with frequent vasomotor symptoms to usual care with or without up to 20 individualized acupuncture treatments over 6 months. Women receiving acupuncture experienced significantly greater reductions in hot flash frequency and improvements in quality-of-life measures, with benefits emerging early and sustained over the study period.

This randomized, placebo-controlled trial found that both Reiki and sham groups showed improvements over time in stress, anxiety, and mood-related symptoms, but there were no consistent statistically significant differences between groups, suggesting Reiki’s effects on mental health symptoms may not exceed placebo.

This systematic review found that preclinical evidence consistently supports neuroprotective and analgesic mechanisms, while clinical studies suggest potential improvements in neuropathic symptoms and function for CIPN. Heterogeneity and limited high-quality randomized trials warrant cautious interpretation of findings.

This meta-analysis pooled RCTs examining Reiki on pain outcomes across diverse patient populations. Pooled results suggested that Reiki was associated with a statistically significant reduction in pain compared to control conditions, although effect sizes were modest and study heterogeneity and risk of bias limited the strength of conclusions.

This RCT compared electro-acupuncture (2–3× per week for 16 weeks), physical exercise, and a no-treatment control in women with PCOS. Electro-acupuncture significantly reduced circulating androgen levels and improved menstrual regularity compared to control, with exercise also showing benefits but generally less pronounced endocrine effects.

This RCT evaluated EMDR therapy in individuals with personality disorders, comparing it to a control condition over approximately 6–12 weeks. Results demonstrated significant reductions in psychological distress and symptom severity in the EMDR group, supporting EMDR as a potentially effective adjunctive treatment for individuals with personality disorders.

This RCT (n=60) assigned women who had recently experienced pregnancy loss to art therapy (4 sessions) or routine care. At 8-week follow-up, the art therapy group showed significantly greater improvements in overall quality of life across physical, psychological, social, and environmental domains, supporting art therapy as an effective complementary intervention after pregnancy loss.

This prospective observational study evaluated an intensive electroacupuncture protocol (5×/week for 4 weeks, then 3×/week for 8 weeks) in women with POI. Results showed significant reductions in FSH and improvements in estradiol and LH levels, suggesting that electroacupuncture may help modulate hypothalamic-pituitary-ovarian axis function in POI patients.

This meta-analysis of RCTs demonstrated that EMDR produced significant reductions in PTSD symptom severity compared to waitlist, usual care, or other psychotherapy control conditions, supporting its effectiveness as a trauma-focused therapy, though variability in study quality and protocols was noted.

This protocol paper outlines a planned RCT comparing EMDR versus CBT for individuals with PTSD and comorbid depressive symptoms over approximately 6–12 weeks, aiming to determine whether EMDR is non-inferior or superior to CBT in reducing trauma-related and depressive symptoms.

This RCT compared EMDR, fluoxetine, and placebo over 8 weeks with 6-month follow-up. EMDR produced significantly greater and more sustained reductions in PTSD symptoms—particularly in adult-onset trauma—while fluoxetine showed more modest improvements and less durability at follow-up.

This meta-analysis of 11 RCTs (n≈661) demonstrated a statistically significant but modest improvement in quality of life (SMD ≈ 0.28), suggesting Reiki may enhance well-being. Subgroup analyses indicated that ≥8 sessions and longer session lengths were associated with greater effects, though effect sizes were small and dependent on treatment dose.

This systematic review and meta-analysis of 12 RCTs (n=1,842) found that patients receiving acupuncture were 21% more likely to experience symptom improvement than those receiving medication alone. Acupuncture significantly decreased self-reported pain intensity and increased the pain threshold, with minimal and mild adverse effects.

This RCT evaluated brief Somatic Experiencing (SE, ~6–8 weekly sessions) for individuals with chronic low back pain and comorbid PTSD. The SE group showed significant reductions in PTSD symptom severity and improvements in pain-related disability compared to usual care alone, though effects on pain intensity were more modest.

This scoping review mapped literature on sound-based interventions (music therapy, singing, sound baths, vibroacoustic approaches) and their effects on mental stress responses. Across highly heterogeneous studies, sound interventions were generally associated with reductions in perceived stress and improvements in physiological stress indicators, though variability in design and methodological quality limits definitive conclusions.

This pre-post study evaluated a single singing bowl massage session in healthy participants. Results showed increases in relaxation-associated brainwave activity (alpha/theta), improvements in autonomic regulation (heart rate variability), and significant reductions in perceived stress and tension, suggesting that singing bowl massage may induce measurable relaxation responses.

This combined in vitro and clinical observational study found that Gui Zhi Fu Ling Wan induced apoptosis and inhibited proliferation in fibroid cells. Clinical findings suggested potential reductions in fibroid-related symptoms and size, supporting a mechanistic basis for its therapeutic use in uterine fibroids.

This randomized, sham-controlled trial found that acupuncture in obese women produced significant reductions in leptin and insulin levels and increases in ghrelin, along with improvements in weight-related measures compared to sham, suggesting a modulatory effect on neuroendocrine pathways involved in obesity.